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CS-W001157 4
Total: USD 88.00

2,4-Difluoro-3-iodopyridine

  • CAS No. 837364-88-2

  • Cat. No. CS-0005569
  • Purity≥98%
  • MDL No.MFCD09029861
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,4-Difluoro-3-iodopyridine|CS-0005569

Structure of 837364-88-2

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Description

2,4-Difluoro-3-iodopyridine serves as a pivotal building block in cross-coupling chemistry, featuring orthogonal reactivity due to its strategically positioned fluorine and iodine substituents. This electron-deficient pyridine enables selective palladium-catalyzed transformations, integrating seamlessly into complex molecular architectures under standard conditions.

Application

2,4-Difluoro-3-iodopyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient palladium-catalyzed transformations due to its orthogonal halogen reactivity. The iodo group facilitates rapid coupling with boronic acids, while the difluoro substitution enhances electrophilicity and improves reaction kinetics. This compound offers excellent bench stability, ease of purification, and compatibility with diverse functional groups, making it ideal for constructing complex heterocyclic scaffolds in medicinal chemistry and agrochemical research.

General Information

  • CAS No. 837364-88-2
  • Cat. No. CS-0005569
  • Purity ≥98%
  • MDL No. MFCD09029861
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂F₂IN
  • Molecular Weight 240.98
  • Synonym(s) Pyridine, 2,4-difluoro-3-iodo-
  • SMILES IC1=C(F)C=CN=C1F

Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.9644
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P501

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