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Structure of 83882-67-1
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1-(4-(Difluoromethoxy)phenyl)ethanone features a para-difluoromethoxy-substituted phenyl ring linked to a ketone group, delivering enhanced lipophilicity and metabolic stability. This scaffold integrates readily into pharmaceutical intermediates, offering improved membrane permeability and resistance to oxidative degradation in synthetic routes.
1-(4-(Difluoromethoxy)phenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically relevant aryl ketones. Its difluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the acetyl moiety facilitates downstream transformations such as nucleophilic additions, reductions, and coupling reactions. The compound exhibits excellent bench stability and is readily purified by recrystallization or flash chromatography, making it well-suited for high-throughput synthesis and scale-up applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: