N-Fmoc-N-ethyl-L-alanine

Name: N-Fmoc-N-ethyl-L-alanine
Brand: ChemScene
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CAS No. 84000-09-9
Cat. No. CS-0378006
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 84000-09-9

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Description

N-Fmoc-N-ethyl-L-alanine integrates a sterically hindered ethyl group at the N-terminus, enhancing solubility and reducing racemization during peptide synthesis. The Fmoc moiety enables efficient, orthogonal deprotection under mild basic conditions, streamlining chain elongation in solid-phase workflows.

Application

N-Fmoc-N-ethyl-L-alanine serves as a versatile building block in peptide synthesis, enabling the incorporation of ethylated amine functionality at the N-terminus. The Fmoc group provides orthogonal protection compatible with standard coupling protocols, while the N-ethyl substitution enhances metabolic stability and modulates solubility. This derivative facilitates efficient chain elongation and purification due to its bench-stable nature and compatibility with common deprotection conditions.

General Information

CAS No. 84000-09-9
Cat. No. CS-0378006
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₂₁NO₄
Molecular Weight 339.39
Synonym(s) N-Ethyl-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-alanine
SMILES OC([C@H](C)N(CC)C(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O

Computational Chemistry Data

TPSA 66.84
LogP 3.7305
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 5

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Alanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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N-Fmoc-N-ethyl-L-alanine

CAS No. 84000-09-9

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