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CS-W001157 4
Total: USD 88.00

Paliperidone impurity 15

  • CAS No. 84163-13-3

  • Cat. No. CS-0005760
  • Molecule weight256.71
  • Purity≥98%
  • MDL No.MFCD06658529

*For research and further manufacturing use only, not for direct human use.

Paliperidone impurity 15|CS-0005760

Structure of 84163-13-3

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General Information

  • CAS No. 84163-13-3
  • Cat. No. CS-0005760
  • Purity ≥98%
  • MDL No. MFCD06658529
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₄ClFN₂O
  • Molecular Weight 256.71
  • Synonym(s) 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
  • SMILES Cl.FC=1C=CC2=C(ON=C2C3CCNCC3)C1

Description

Zirconium oxide (ZrO2) is a metal oxide with mechanical strength similar to steel hence referred to as ceramic steel. Some of its other properties include high biocompatibility, chemical inertness, resistance to corrosion, high dielectric constant, large bandgap, and high thermal resistance. Pure zirconia is susceptible to fracture due to phase transformation at elevated temperature which can be overcome by adding stabilizers such as yttria to form yttrium-stabilized zirconia or yttria tetragonal zirconia polycrystals.Currently, titanium and its alloys are widely used in implant dentistry. But they pose challenges such as potential immunologic response and its dark grayish color which affects the esthetics. The natural white color, mechanical properties, higher osseointegration, and biocompatibility of ZrO2 make it an ideal candidate as a dental biomaterial for implants and crowns compared to titanium-based systems.The doping of ZrO2 with Ce4+ ions makes it photosensitive to visible light leading to the formation of a 3rd generation photoactive system with potential applications in photocatalysis.

Application

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles via standard coupling and functionalization reactions. Its fluorinated benzisoxazole core offers enhanced metabolic stability and favorable pharmacokinetic properties, while the piperidine moiety provides a handle for further derivatization. The hydrochloride salt ensures excellent bench stability, solubility, and ease of purification—ideal for high-throughput synthesis and lead optimization campaigns.

Synthesis

  • Route1
    • null|null
      416852-17-0
    • ~%
    • In-stock
      Paliperidone impurity 15|CS-0005760
      84163-13-3

    References

    • WO2008/108957 A2, ; Page/Page column 36 ;
  • Route2
    • null|null
      84163-41-7
    • ~%
    • In-stock
      Paliperidone impurity 15|CS-0005760
      84163-13-3

    References

    • Journal of Medicinal Chemistry, , vol. 28, # 6 p. 761 - 769
  • Route3
    • null|null
      84162-94-7
    • ~%
    • In-stock
      Paliperidone impurity 15|CS-0005760
      84163-13-3

    References

    • Journal of Medicinal Chemistry, , vol. 28, # 6 p. 761 - 769

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.06
  • LogP   2.8557
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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