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CS-W001157 4
Total: USD 88.00

4-Cyano-3-fluorophenylboronic acid

  • CAS No. 843663-18-3

  • Cat. No. CS-M1589
  • Purity≥95%
  • MDL No.MFCD03411549
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Cyano-3-fluorophenylboronic acid|CS-M1589

Structure of 843663-18-3

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Description

4-Cyano-3-fluorophenylboronic acid features a boronic acid group flanked by electron-withdrawing cyano and fluorine substituents, enhancing its stability and reactivity in Suzuki-Miyaura coupling. This combination enables efficient cross-coupling under mild conditions, delivering arylated products with high fidelity. The molecule's bench-stable nature simplifies handling in synthetic workflows.

Application

4-Cyano-3-fluorophenylboronic acid serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under standard Suzuki-Miyaura conditions. The ortho-fluoro and cyano groups provide enhanced reactivity and stability, facilitating selective functionalization in complex molecule synthesis. Its bench-stable solid form simplifies handling and purification, making it ideal for medicinal chemistry and process development workflows.

General Information

  • CAS No. 843663-18-3
  • Cat. No. CS-M1589
  • Purity ≥95%
  • MDL No. MFCD03411549
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BFNO₂
  • Molecular Weight 164.93
  • Synonym(s) Boronic acid, B-(4-cyano-3-fluorophenyl)-
  • SMILES FC1=CC(B(O)O)=CC=C1C#N

Computational Chemistry Data

  • TPSA   64.25
  • LogP   -0.62282
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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