2-Bromo-5-difluoromethoxy-pyridine

Name: 2-Bromo-5-difluoromethoxy-pyridine
Brand: ChemScene
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CAS No. 845827-14-7
Cat. No. CS-D0409
Purity≥98%
MDL No.MFCD13185842

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Bromo-5-difluoromethoxy-pyridine|CS-D0409

Structure of 845827-14-7

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Description

2-Bromo-5-difluoromethoxy-pyridine features a difluoromethoxy group at the 5-position and a bromine atom at the 2-position, enabling selective cross-coupling reactions. This electron-deficient pyridine serves as a key building block in pharmaceutical synthesis, offering enhanced reactivity and stability under standard conditions.

Application

2-Bromo-5-difluoromethoxy-pyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromine at C2. The difluoromethoxy group at C5 imparts enhanced metabolic stability and modulates lipophilicity, while the pyridine core provides a robust scaffold for further functionalization. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient assembly of complex heterocyclic architectures.

General Information

CAS No. 845827-14-7
Cat. No. CS-D0409
Purity ≥98%
MDL No. MFCD13185842
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄BrF₂NO
Molecular Weight 224.00
Synonym(s) 2-Bromo-5-(difluoromethoxy)pyridine
SMILES FC(F)OC1=CN=C(Br)C=C1

Computational Chemistry Data

TPSA 22.12
LogP 2.4455
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Bromo-5-difluoromethoxy-pyridine

CAS No. 845827-14-7

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