Boc-Lys(Fmoc)-OH

Name: Boc-Lys(Fmoc)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 84624-27-1
Cat. No. CS-W005144
Purity≥98%
MDL No.MFCD00062032

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 84624-27-1

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Description

Boc-Lys(Fmoc)-OH is a protected lysine derivative featuring orthogonal side-chain and α-amino group masking. The Fmoc moiety enables base-labile deprotection in solid-phase peptide synthesis, while the Boc group provides stable protection of the ε-amino function under acidic conditions. This dual protection strategy facilitates selective functionalization and efficient incorporation into complex peptide sequences.

Application

Boc-Lys(Fmoc)-OH serves as a key di-functional amino acid building block for peptide synthesis, enabling orthogonal protection of both α-amino and ε-amino groups. The Boc group provides stable Nα-protection suitable for acid-labile deprotection, while the Fmoc moiety allows for mild base-cleavable side-chain protection. This dual protection strategy facilitates efficient sequential coupling in solid-phase peptide synthesis, supports high-purity product formation, and simplifies purification due to enhanced solubility and chromatographic behavior.

General Information

CAS No. 84624-27-1
Cat. No. CS-W005144
Purity ≥98%
MDL No. MFCD00062032
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₆H₃₂N₂O₆
Molecular Weight 468.54
Synonym(s) None
SMILES O=C(O)[C@H](CCCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)NC(OC(C)(C)C)=O

Computational Chemistry Data

TPSA 113.96
LogP 4.6733
H_Acceptors 5
H_Donors 3
Rotatable_Bonds 9

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Life Science Amino Acids and their Derivatives Lysine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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Boc-Lys(Fmoc)-OH

CAS No. 84624-27-1

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