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CS-W001157 4
Total: USD 88.00

tert-Butyl 2-amino-2-methylpropanoate hydrochloride

  • CAS No. 84758-81-6

  • Cat. No. CS-W019407
  • Purity≥97%
  • MDL No.MFCD08272284

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-amino-2-methylpropanoate hydrochloride|CS-W019407

Structure of 84758-81-6

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General Information

  • CAS No. 84758-81-6
  • Cat. No. CS-W019407
  • Purity ≥97%
  • MDL No. MFCD08272284
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈ClNO₂
  • Molecular Weight 195.69
  • Synonym(s) tert-Butyl 2-Amino-2-methylpropionate Hydrochloride
  • SMILES CC(C)(N)C(OC(C)(C)C)=O.[H]Cl

Description

tert-Butyl 2-amino-2-methylpropanoate hydrochloride features a sterically hindered tertiary amine scaffold paired with a protected α-amino acid moiety, enabling robust incorporation into peptide synthesis workflows. This bench-stable derivative delivers efficient coupling under standard conditions while minimizing epimerization risks during activation.

Application

tert-Butyl 2-amino-2-methylpropanoate hydrochloride serves as a stable, bench-ready building block for the synthesis of sterically hindered amino acid derivatives and peptidomimetics. The protected amine enables straightforward deprotection under mild acidic conditions, while the tert-butyl ester supports orthogonal functionalization. Its high solubility in common organic solvents facilitates purification and scalability, making it ideal for iterative coupling strategies in medicinal chemistry and process development.

Synthesis

  • Route1
    • Tert-butyl 2-(benzyloxycarbonylamino)-2-methylpropanoate|CS-0747005
      4512-31-6
    • ~76%
    • In-stock
      tert-Butyl 2-amino-2-methylpropanoate hydrochloride|CS-W019407
      84758-81-6

    References

    • Leibfritz, Dieter; Haupt, Erhard; Dubischar, Norbert; Lachmann, Heinrich; Oekonomopulos, Raymond; Jung, Guenther Tetrahedron, 1982 , vol. 38, # 14 p. 2165 - 2182

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   1.4872
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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