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Structure of 848438-50-6
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4-Chloroquinazolin-6-ol is a bench-stable heterocyclic scaffold featuring a chlorine substituent at the 4-position and a phenolic hydroxyl group at the 6-position. This configuration enables direct integration into bioactive molecules, where the electron-deficient core supports hydrogen bonding and π-stacking interactions critical in kinase inhibitor design.
4-Chloroquinazolin-6-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C6 position via nucleophilic substitution or transition-metal-catalyzed coupling. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient access to quinazoline-based scaffolds prevalent in kinase inhibitors and antitumor agents. The chlorine substituent provides a reliable handle for downstream derivatization, while the hydroxyl group offers orthogonal reactivity for protection or conjugation.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319
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Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: