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CS-W001157 4
Total: USD 88.00

5-Bromo-2-(tert-butoxy)pyridine

  • CAS No. 850495-91-9

  • Cat. No. CS-0231666
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-(tert-butoxy)pyridine|CS-0231666

Structure of 850495-91-9

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Description

5-Bromo-2-(tert-butoxy)pyridine features a sterically shielded tert-butoxy group at the 2-position, enhancing stability and solubility in organic media. The electron-deficient pyridine ring pairs with the bromo substituent at C5 to enable efficient coupling reactions. This bench-stable reagent integrates readily into cross-coupling protocols for constructing complex heterocyclic architectures under mild conditions.

Application

5-Bromo-2-(tert-butoxy)pyridine serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient access to functionalized pyridine scaffolds. The tert-butoxy group provides excellent stability and facilitates selective derivatization, while the bromide supports reliable Suzuki, Stille, and Negishi couplings. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for medicinal chemistry and process development workflows.

General Information

  • CAS No. 850495-91-9
  • Cat. No. CS-0231666
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂BrNO
  • Molecular Weight 230.10
  • Synonym(s) 5-BROMO-2-TERT-BUTOXY-PYRIDINE
  • SMILES CC(C)(C)OC1=NC=C(C=C1)Br

Computational Chemistry Data

  • TPSA   22.12
  • LogP   3.0214
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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