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Structure of 851755-45-8
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This difluoromethoxy-substituted thiazole carboxylic acid features a sterically accessible carboxyl group paired with a moisture-tolerant, electron-deficient heterocyclic core. The para-positioned difluoromethoxy moiety enhances metabolic stability and modulates lipophilicity, enabling direct incorporation into bioactive scaffolds for medicinal chemistry applications.
4-(Difluoromethoxy)-2-methylthiazole-5-carboxylic acid serves as a versatile building block for medicinal chemistry and agrochemical research, enabling the construction of thiazole-based heterocyclic scaffolds. The difluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the carboxylic acid functionality facilitates direct amidation, esterification, or coupling reactions. Bench-stable and compatible with standard synthetic protocols, it functions effectively in peptide conjugation, macrocyclization, and diversity-oriented synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: