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CS-W001157 4
Total: USD 88.00

1-Cyclopropylpiperidin-4-ol

  • CAS No. 851847-62-6

  • Cat. No. CS-0035132
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Cyclopropylpiperidin-4-ol|CS-0035132

Structure of 851847-62-6

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General Information

  • CAS No. 851847-62-6
  • Cat. No. CS-0035132
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅NO
  • Molecular Weight 141.21
  • Synonym(s) 1-cyclopropyl-4-Piperidinol
  • SMILES OC1CCN(C2CC2)CC1

Description

1-Cyclopropylpiperidin-4-ol features a rigid cyclopropyl ring fused to a piperidine scaffold, delivering enhanced metabolic stability and improved membrane permeability. The pendant hydroxyl group enables direct functionalization or hydrogen bonding interactions in medicinal chemistry applications. This scaffold serves as a key building block for CNS-targeted therapeutics and bioactive small molecules.

Application

1-Cyclopropylpiperidin-4-ol serves as a valuable scaffold in medicinal chemistry, enabling the construction of bioactive molecules through established functional group transformations. Its cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, while the pendant hydroxyl group offers direct handle for derivatization. The compound exhibits good bench stability and compatibility with standard coupling protocols, facilitating efficient synthesis of complex heterocyclic systems and API intermediates.

Synthesis

  • Route1
    • null|null
      62813-01-8
    • ~96%
    • In-stock
      1-Cyclopropylpiperidin-4-ol|CS-0035132
      851847-62-6

    References

    • Pierson, Pascale David; Fettes, Alec; Freichel, Christian; Gatti-McArthur, Silvia; Hertel, Cornelia; Huwyler, Joerg; Mohr, Peter; Nakagawa, Toshito; Nettekoven, Matthias; Plancher, Jean-Marc; Raab, Susanne; Richter, Hans; Roche, Olivier; Sarmiento, Rosa Maria Rodriguez; Schmitt, Monique; Schuler, Franz; Takahashi, Tadakatsu; Taylor, Sven; Ullmer, Christoph; Wiegand, Ruby Journal of Medicinal Chemistry, 2009 , vol. 52, # 13 p. 3855 - 3868

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   0.6055
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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