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CS-W001157 4
Total: USD 88.00

3-(3,5-Dichlorophenyl)piperidine

  • CAS No. 851861-61-5

  • Cat. No. CS-0162677
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(3,5-Dichlorophenyl)piperidine|CS-0162677

Structure of 851861-61-5

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General Information

  • CAS No. 851861-61-5
  • Cat. No. CS-0162677
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃Cl₂N
  • Molecular Weight 230.13
  • Synonym(s) None
  • SMILES ClC1=CC(Cl)=CC(C2CNCCC2)=C1

Description

3-(3,5-Dichlorophenyl)piperidine is a sterically defined piperidine derivative featuring a dichlorinated phenyl ring at the 3-position. This configuration imparts enhanced lipophilicity and metabolic stability, enabling efficient integration into bioactive molecules. The compound serves as a key scaffold in medicinal chemistry for targeting CNS receptors and modulating pharmacokinetic profiles.

Application

3-(3,5-Dichlorophenyl)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard coupling and functionalization reactions. Its electron-deficient aryl group enhances metabolic stability, while the piperidine core provides a basic nitrogen for salt formation and hydrogen bonding. The compound exhibits good bench stability and is compatible with common purification methods, facilitating integration into multi-step syntheses of pharmaceutical candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   3.4604
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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