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CS-W001157 4
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2-Ethoxypyridine-3-boronic acid

  • CAS No. 854373-97-0

  • Cat. No. CS-0030448
  • Purity≥97%
  • MDL No.MFCD06201036

*For research and further manufacturing use only, not for direct human use.

2-Ethoxypyridine-3-boronic acid|CS-0030448

Structure of 854373-97-0

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General Information

  • CAS No. 854373-97-0
  • Cat. No. CS-0030448
  • Purity ≥97%
  • MDL No. MFCD06201036
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀BNO₃
  • Molecular Weight 166.97
  • Synonym(s) boronic acid, B-(2-ethoxy-3-pyridinyl)-
  • SMILES CCOC1=NC=CC=C1B(O)O

Description

2-Ethoxypyridine-3-boronic acid features a pyridine ring bearing both ethoxy and boronic acid groups, enabling direct incorporation into Suzuki-Miyaura cross-coupling reactions. The electron-deficient pyridine moiety enhances reactivity, while the boronic acid functionality offers stability under standard conditions. This compound serves as a key building block for bioactive heterocycles and functionalized materials.

Application

2-Ethoxypyridine-3-boronic acid serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its pyridyl boronic acid functionality exhibits excellent stability, solubility in common organic solvents, and compatibility with diverse functional groups, facilitating straightforward purification and integration into complex molecular architectures.

Synthesis

  • Route1
    • null|null
      14529-53-4
    • ~67%
    • In-stock
      2-Ethoxypyridine-3-boronic acid|CS-0030448
      854373-97-0

    References

    • Thompson, Amy E.; Batsanov, Andrei S.; Bryce, Martin R.; Saygili, Nezire; Parry, Paul R.; Tarbit, Brian Tetrahedron, 2005 , vol. 61, # 21 p. 5131 - 5135

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.58
  • LogP   -0.8399
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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