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CS-W001157 4
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[1,3]Thiazolo[5,4-b]pyridine-2-carboxylic acid

  • CAS No. 857969-93-8

  • Cat. No. CS-0058164
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

[1,3]Thiazolo[5,4-b]pyridine-2-carboxylic acid|CS-0058164

Structure of 857969-93-8

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General Information

  • CAS No. 857969-93-8
  • Cat. No. CS-0058164
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄N₂O₂S
  • Molecular Weight 180.18
  • Synonym(s) Thiazolo[5,4-b]pyridin-2-carbonsaeure
  • SMILES C1=CC2=C(N=C1)SC(=N2)C(=O)O

Description

This thiazolopyridine carboxylic acid features a fused heterocyclic core with defined electron-deficient character, enabling robust integration into bioactive scaffolds. The carboxylic acid group provides a versatile handle for conjugation and derivatization under standard conditions, supporting applications in medicinal chemistry and materials science.

Application

[1,3]Thiazolo[5,4-b]pyridine-2-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its fused thiazole-pyridine core provides enhanced rigidity and electronic properties, while the carboxylic acid group enables direct derivatization via amide coupling or esterification. The scaffold exhibits good bench stability and functional group tolerance, facilitating integration into diverse synthetic workflows including peptide conjugation and macrocyclization.

Synthesis

  • Route1

    References

    • Fridman Zhurnal Obshchei Khimii, 1956 , vol. 26, p. 864,866; engl. Ausg. S. 985, 986

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   1.3895
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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