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Structure of 860296-21-5
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4-Chloro-3-fluoropyridine-2-carboxylic acid features a fused heterocyclic core with orthogonal electron-withdrawing substituents enabling precise tuning of reactivity. The carboxylic acid group facilitates direct coupling in peptide and macrocyclization workflows, while the fluorine and chlorine atoms enhance metabolic stability and membrane permeability. This scaffold integrates readily into bioactive molecules requiring controlled polarity and targeted electrophilicity.
4-Chloro-3-fluoropyridine-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive heterocycles via standard coupling reactions. The ortho-halogen and carboxylic acid functionalities provide complementary reactivity for Suzuki-Miyaura, Buchwald-Hartwig, and amide formation, facilitating rapid diversification. Bench-stable and compatible with common protecting group strategies, it supports scalable synthesis of pyridine-based API candidates with enhanced metabolic stability.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: