1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid

Name: 1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 860496-20-4
Cat. No. CS-W019708
Purity≥97%
MDL No.MFCD11559014

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid|CS-W019708

Structure of 860496-20-4

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Description

1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid features a fused heterocyclic core with a carboxylic acid group at the 3-position, enabling direct conjugation or derivatization in synthetic routes. The electron-deficient pyrrolopyridine scaffold enhances reactivity in cross-coupling and cyclization processes, while the acidic proton supports salt formation for improved solubility and handling. This structure serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its rigid fused scaffold enables predictable bioactive conformation and facilitates functionalization at the carboxylic acid terminus. The molecule exhibits good bench stability, moderate solubility in common organic solvents, and compatibility with standard coupling reactions, including amide formation and esterification, supporting efficient access to diverse analogs in lead optimization campaigns.

General Information

CAS No. 860496-20-4
Cat. No. CS-W019708
Purity ≥97%
MDL No. MFCD11559014
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆N₂O₂
Molecular Weight 162.15
Synonym(s) None
SMILES O=C(C1=CNC2=CC=CN=C21)O

Computational Chemistry Data

TPSA 65.98
LogP 1.2611
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrrole compounds

Key Words

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1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid

CAS No. 860496-20-4

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