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CS-W001157 4
Total: USD 88.00

Fmoc-Cys(Acm)-OH

  • CAS No. 86060-81-3

  • Cat. No. CS-W013859
  • Molecule weight414.47
  • Purity≥98%
  • MDL No.MFCD00038769

*For research and further manufacturing use only, not for direct human use.

Fmoc-Cys(Acm)-OH|CS-W013859

Structure of 86060-81-3

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General Information

  • CAS No. 86060-81-3
  • Cat. No. CS-W013859
  • Purity ≥98%
  • MDL No. MFCD00038769
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₂N₂O₅S
  • Molecular Weight 414.47
  • Synonym(s) None
  • SMILES O=C([C@@H](NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)CSCNC(C)=O)O

Description

Fmoc-Cys(Acm)-OH is a protected cysteine derivative designed for site-specific incorporation in peptide synthesis. The Acm (acetamidomethyl) group provides orthogonal protection for the thiol side chain, enabling selective deprotection under mild oxidative conditions. This facilitates disulfide bond formation or further functionalization in complex peptide architectures. The Fmoc moiety ensures efficient N-terminal protection during solid-phase synthesis. Stable under standard bench conditions and compatible with common coupling protocols.

Synthesis

  • Route1
    • null|null
      718635-75-7
    • ~83%
    • In-stock
      Fmoc-Cys(Acm)-OH|CS-W013859
      86060-81-3

    References

    • European Journal of Organic Chemistry, , # 21 p. 4437 - 4441
  • Route2
    • H-Cys(Acm)-OH|CS-0636612
      19647-70-2
    • null|null
      28920-43-6
    • ~74%
    • In-stock
      Fmoc-Cys(Acm)-OH|CS-W013859
      86060-81-3

    References

    • Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2057 - 2064
  • Route3
    • null|null
      28920-44-7
    • null|null
      111082-99-6
    • ~60%
    • In-stock
      Fmoc-Cys(Acm)-OH|CS-W013859
      86060-81-3

    References

    • Synthesis, , # 3 p. 271 - 272

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   104.73
  • LogP   2.8051
  • H_Acceptors   5
  • H_Donors   3
  • Rotatable_Bonds   8

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