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N-Methoxy-N-methyl-1H-imidazole-1-carboxamide

  • CAS No. 862873-06-1

  • Cat. No. CS-0438973
  • Purity≥98%
  • MDL No.MFCD21608484

*For research and further manufacturing use only, not for direct human use.

N-Methoxy-N-methyl-1H-imidazole-1-carboxamide|CS-0438973

Structure of 862873-06-1

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General Information

  • CAS No. 862873-06-1
  • Cat. No. CS-0438973
  • Purity ≥98%
  • MDL No. MFCD21608484
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃O₂
  • Molecular Weight 155.15
  • Synonym(s) N-METHOXY-N-METHYL-1H-IMIDAZOLE-1-CARBO&
  • SMILES O=C(N1C=CN=C1)N(OC)C

Description

N-Methoxy-N-methyl-1H-imidazole-1-carboxamide serves as a potent, bench-stable amidation reagent, featuring a reactive imidazole carboxamide core paired with a methoxy-methyl group that enhances electrophilicity. This combination enables efficient coupling under mild conditions, streamlining amide bond formation in synthetic workflows.

Application

N-Methoxy-N-methyl-1H-imidazole-1-carboxamide serves as a versatile acyl transfer reagent, enabling efficient amide bond formation under mild conditions. Its stability in air and moisture facilitates handling, while its compatibility with diverse nucleophiles simplifies purification. Functions as a reliable alternative to hazardous reagents in peptide coupling and synthetic route optimization.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   47.36
  • LogP   0.3444
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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