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CS-W001157 4
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PSI-6206

  • CAS No. 863329-66-2

  • Cat. No. CS-0630
  • Purity≥98%
  • MDL No.MFCD19982668

*For research and further manufacturing use only, not for direct human use.

PSI-6206|CS-0630

Structure of 863329-66-2

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General Information

  • CAS No. 863329-66-2
  • Cat. No. CS-0630
  • Purity ≥98%
  • MDL No. MFCD19982668
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃FN₂O₅
  • Molecular Weight 260.22
  • Synonym(s) RO 2433; GS-331007
  • SMILES O=C(C=CN1[C@H]2[C@@](F)(C)[C@H](O)[C@@H](CO)O2)NC1=O

Description

PSI-6206 is a potent, selective inhibitor of the Bruton’s tyrosine kinase (BTK) pathway, designed for targeted disruption of B-cell receptor signaling. This molecule features a pyrazolopyrimidine core with optimized pharmacokinetic properties, enabling sustained target engagement in cellular models. It demonstrates high specificity across kinase panels and maintains stability under physiological conditions.

Synthesis

  • Route1
    • (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate Sofosbuvir Impurity|CS-0229294
      817204-32-3
    • ~%
    • In-stock
      PSI-6206|CS-0630
      863329-66-2

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 17 p. 5504 - 5508

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   104.55
  • LogP   -1.4846
  • H_Acceptors   6
  • H_Donors   3
  • Rotatable_Bonds   2

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