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Structure of 86392-75-8
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7-Deaza-2'-dG features a modified purine scaffold with nitrogen at position 7 replaced by carbon, enhancing stability and altering electronic properties. This analog integrates readily into oligonucleotides, offering improved resistance to enzymatic degradation while maintaining efficient base pairing. Ideal for probing nucleic acid structure-function relationships and developing robust antisense agents.
7-Deaza-2'-dG serves as a valuable nucleoside building block for the synthesis of modified oligonucleotides, offering enhanced stability and altered base-pairing properties. Its 7-deaza modification reduces susceptibility to oxidative degradation while maintaining compatibility with standard phosphoramidite coupling protocols. The 2'-deoxy configuration supports efficient incorporation into DNA strands, making it particularly useful in antisense and siRNA applications requiring improved nuclease resistance and predictable hybridization behavior.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: