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Fmoc-NH-ethyl-SS-propionic acid

  • CAS No. 864235-83-6

  • Cat. No. CS-0115547
  • Molecule weight403.52
  • Purity≥98%
  • MDL No.MFCD22380332

*For research and further manufacturing use only, not for direct human use.

Fmoc-NH-ethyl-SS-propionic acid|CS-0115547

Structure of 864235-83-6

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General Information

  • CAS No. 864235-83-6
  • Cat. No. CS-0115547
  • Purity ≥98%
  • MDL No. MFCD22380332
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₂₁NO₄S₂
  • Molecular Weight 403.52
  • Synonym(s) None
  • SMILES O=C(O)CCSSCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

Fmoc-NH-ethyl-SS-propionic acid features a disulfide-linked ethyl spacer flanked by propionic acid and Fmoc-protected amine functionalities. This bifunctional reagent enables site-specific conjugation in peptide synthesis, where the cleavable disulfide bond facilitates controlled release under reducing conditions. The Fmoc group ensures orthogonal protection during solid-phase assembly, while the ethyl-SS bridge provides stability and efficient coupling efficiency.

Application

Fmoc-NH-ethyl-SS-propionic acid serves as a versatile cysteine-derived building block for disulfide-linked peptide conjugates and antibody-drug conjugates. Its Fmoc group enables efficient solid-phase peptide synthesis, while the disulfide bond provides site-specific cleavage under reducing conditions. The ethyl-SS-propionic acid spacer offers enhanced stability and controlled release, facilitating purification and enabling robust synthetic workflows in bioconjugation applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   4.3812
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   9

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