4-Bromo-6-methylpyridin-2(1H)-one

Name: 4-Bromo-6-methylpyridin-2(1H)-one
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 865156-59-8
Cat. No. CS-W006106
Molecule weight188.02
Purity≥98%
MDL No.MFCD16610030

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Bromo-6-methylpyridin-2(1H)-one|CS-W006106

Structure of 865156-59-8

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 865156-59-8
Cat. No. CS-W006106
Purity ≥98%
MDL No. MFCD16610030
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆BrNO
Molecular Weight 188.02
Synonym(s) 4-Bromo-6-methylpyridin-2-ol
SMILES O=C1C=C(Br)C=C(C)N1

Description

4-Bromo-6-methylpyridin-2(1H)-one features a brominated pyridinone core with a methyl group at the 6-position, offering a robust scaffold for transition metal-catalyzed coupling reactions. The electron-deficient ring facilitates nucleophilic substitution, while the carbonyl and adjacent nitrogen provide coordination sites for metal complexes. This bench-stable compound integrates efficiently into pharmaceutical intermediates and functional materials.

Application

4-Bromo-6-methylpyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its bromine substituent. The pyridinone core provides enhanced solubility and hydrogen-bonding capacity, while the methyl group offers mild steric influence and metabolic stability. This compound facilitates efficient synthesis of heterocyclic scaffolds relevant to kinase inhibitors and other bioactive molecules, with robust bench stability and straightforward purification via crystallization or chromatography.

Synthesis

Route1
- In-stock
  
  3749-51-7
- ~%
- In-stock
  
  865156-59-8
References
- WO2005/90305 A1, ; Page/Page column 33 ; WO 2005/090305 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 32.86
LogP 1.44582
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

4-Bromo-6-methylpyridin-2(1H)-one sigma4-Bromo-6-methylpyridin-2(1H)-one manufacturer4-Bromo-6-methylpyridin-2(1H)-one price4-Bromo-6-methylpyridin-2(1H)-one structure4-Bromo-6-methylpyridin-2(1H)-one SDSbuy 4-Bromo-6-methylpyridin-2(1H)-one4-Bromo-6-methylpyridin-2(1H)-one supplier4-Bromo-6-methylpyridin-2(1H)-one uses4-Bromo-6-methylpyridin-2(1H)-one molecular weightprice of 4-Bromo-6-methylpyridin-2(1H)-one4-Bromo-6-methylpyridin-2(1H)-one chemical name formula of 4-Bromo-6-methylpyridin-2(1H)-one

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Bromo-6-methylpyridin-2(1H)-one

CAS No. 865156-59-8

Recommended Products