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CS-W001157 4
Total: USD 88.00

6-Chloro-5-fluoropyridin-3-ol

  • CAS No. 870062-76-3

  • Cat. No. CS-W003046
  • Purity≥97%
  • MDL No.MFCD03411573

*For research and further manufacturing use only, not for direct human use.

6-Chloro-5-fluoropyridin-3-ol|CS-W003046

Structure of 870062-76-3

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General Information

  • CAS No. 870062-76-3
  • Cat. No. CS-W003046
  • Purity ≥97%
  • MDL No. MFCD03411573
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClFNO
  • Molecular Weight 147.54
  • Synonym(s) 3-pyridinol, 6-chloro-5-fluoro-
  • SMILES Oc1cnc(c(c1)F)Cl

Description

6-Chloro-5-fluoropyridin-3-ol features a trifunctional pyridine core bearing chlorine, fluorine, and hydroxyl groups at strategic positions. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds, offering enhanced metabolic stability and directional reactivity in cross-coupling processes. The hydroxyl group enables direct derivatization or hydrogen bonding interactions in target binding.

Application

6-Chloro-5-fluoropyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its ortho-halogenated pyridinol scaffold offers excellent stability and compatibility with diverse reaction conditions, facilitating the construction of complex heterocyclic frameworks. The molecule's defined electronic profile enhances regioselective transformations, making it ideal for synthesizing API candidates and advanced intermediates in drug discovery workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.5797
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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