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*For research and further manufacturing use only, not for direct human use.
Structure of 870487-10-8
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Boc-Val-Cit-PAB-PNP is a cleavable linker designed for antibody-drug conjugates, featuring a para-aminobenzyl alcohol (PAB) spacer and a phenylalanine-based cleavage site. This construct enables efficient intracellular release of payload following proteolytic processing, combining stability in circulation with targeted activation in lysosomal environments.
Boc-Val-Cit-PAB-PNP serves as a stable, bench-ready linker for antibody-drug conjugates, enabling efficient conjugation via the PAB moiety. The Val-Cit dipeptide provides protease-sensitive cleavage, while the Boc group ensures stability during synthesis and storage. Its orthogonal functionalization profile facilitates reliable coupling in standard bioconjugation workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: