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CS-W001157 4
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3-Benzyloxy-2,6-difluorophenylboronic acid

  • CAS No. 870718-07-3

  • Cat. No. CS-W012453
  • Purity≥98%
  • MDL No.MFCD06200705
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Benzyloxy-2,6-difluorophenylboronic acid|CS-W012453

Structure of 870718-07-3

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Description

3-Benzyloxy-2,6-difluorophenylboronic acid features a strategically positioned benzyloxy group and two fluorine atoms that enhance electronic effects and metabolic stability. This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, delivering functionalized aryl scaffolds with high efficiency and excellent tolerance to diverse reaction environments.

Application

3-Benzyloxy-2,6-difluorophenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-fluoro substituents enhance reactivity through stabilizing electronic effects and facilitate directed metalation, while the benzyloxy group provides orthogonal protection for phenolic functionalities. Its bench-stable nature and compatibility with diverse reaction partners make it well-suited for iterative synthesis of complex aryl architectures in medicinal chemistry and materials science applications.

General Information

  • CAS No. 870718-07-3
  • Cat. No. CS-W012453
  • Purity ≥98%
  • MDL No. MFCD06200705
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₁BF₂O₃
  • Molecular Weight 264.04
  • Synonym(s) [3-(benzyloxy)-2,6-difluorophenyl]boronic acid
  • SMILES OB(C1=C(F)C=CC(OCC2=CC=CC=C2)=C1F)O

Computational Chemistry Data

  • TPSA   49.69
  • LogP   1.2236
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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