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Structure of 871013-92-2
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tert-Butyl 4-hydroxy-2,3-dihydro-1H-isoindole-2-carboxylate is a bench-stable, moisture-tolerant heterocyclic building block featuring a phenolic hydroxyl group flanked by a protected carboxylate. This scaffold enables direct functionalization at the 4-position and integrates readily into complex molecular architectures for medicinal chemistry campaigns.
tert-Butyl 4-hydroxy-2,3-dihydro-1H-isoindole-2-carboxylate serves as a versatile building block for the synthesis of isoindoline-based scaffolds prevalent in medicinal chemistry. The hydroxyl group enables direct functionalization via esterification, etherification, or oxidation to quinone intermediates. Its tert-butyl carbamate protects the nitrogen during multi-step sequences, offering stability and ease of deprotection under mild acidic conditions. This compound exhibits excellent bench stability and compatibility with standard coupling reactions, facilitating efficient access to complex heterocycles and bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
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Lot numbers can be found on the outside label of a product: