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CS-W001157 4
Total: USD 88.00

2-(4-Bromobutyl)-1,3-dioxolane

  • CAS No. 87227-41-6

  • Cat. No. CS-D0360
  • Molecule weight209.08
  • Purity≥96%
  • MDL No.MFCD02093454

*For research and further manufacturing use only, not for direct human use.

2-(4-Bromobutyl)-1,3-dioxolane|CS-D0360

Structure of 87227-41-6

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General Information

  • CAS No. 87227-41-6
  • Cat. No. CS-D0360
  • Purity ≥96%
  • MDL No. MFCD02093454
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃BrO₂
  • Molecular Weight 209.08
  • Synonym(s) None
  • SMILES BrCCCCC1OCCO1

Description

This 2-(4-Bromobutyl)-1,3-dioxolane features a bromoalkyl chain tethered to a stable dioxolane ring, enabling efficient coupling in synthetic transformations. The electron-deficient bromide facilitates nucleophilic substitution, while the cyclic acetal offers enhanced stability and solubility in organic media.

Application

2-(4-Bromobutyl)-1,3-dioxolane serves as a versatile bifunctional building block for synthetic organic chemistry, combining a reactive alkyl bromide with a stable 1,3-dioxolane protecting group. The bromide enables efficient nucleophilic substitution and coupling reactions, while the dioxolane moiety offers excellent bench stability and orthogonal protection for diols. This compound facilitates the construction of complex heterocyclic scaffolds and functionalized chains in medicinal chemistry and materials synthesis workflows.

Synthesis

  • Route1
    • null|null
      1191-30-6
    • In-stock
      Ethylene glycol,98%|CS-0015059
      107-21-1
    • ~82%
    • In-stock
      2-(4-Bromobutyl)-1,3-dioxolane|CS-D0360
      87227-41-6

    References

    • Baker; Little Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 46 - 50
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 28, # 1 p. 46 - 50
  • Route3

    References

    • Farmaco, , vol. 47, # 3 p. 379 - 385

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   1.9245
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

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