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CS-W001157 4
Total: USD 88.00

(4-(Dimethylcarbamoyl)-2-fluorophenyl)boronic acid

  • CAS No. 874289-30-2

  • Cat. No. CS-0141571
  • Purity≥96%
  • MDL No.MFCD11855833

*For research and further manufacturing use only, not for direct human use.

(4-(Dimethylcarbamoyl)-2-fluorophenyl)boronic acid|CS-0141571

Structure of 874289-30-2

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General Information

  • CAS No. 874289-30-2
  • Cat. No. CS-0141571
  • Purity ≥96%
  • MDL No. MFCD11855833
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁BFNO₃
  • Molecular Weight 211.00
  • Synonym(s) 4-(Dimethylcarbamoyl)-2-fluorophenylboronic acid
  • SMILES OB(C1=CC=C(C(N(C)C)=O)C=C1F)O

Description

This boronic acid features a dimethylcarbamoyl group at the 4-position and fluorine at the 2-position, delivering enhanced stability and solubility in polar solvents. The electron-withdrawing fluorine modulates reactivity, while the carbamoyl moiety improves handling and compatibility in Suzuki-Miyaura coupling reactions under standard conditions.

Application

(4-(Dimethylcarbamoyl)-2-fluorophenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The dimethylcarbamoyl group enhances solubility and stability, while the fluorine substituent provides orthogonal reactivity for downstream functionalization. This boronic acid exhibits excellent bench stability, simplifies purification, and tolerates a broad range of functional groups, making it well-suited for medicinal chemistry and process-scale synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.77
  • LogP   -0.7927
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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