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CS-W001157 4
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2-Hydroxy-4-methylthiazole-5-carboxylic acid

  • CAS No. 875237-46-0

  • Cat. No. CS-0187813
  • Molecule weight159.16
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-4-methylthiazole-5-carboxylic acid|CS-0187813

Structure of 875237-46-0

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General Information

  • CAS No. 875237-46-0
  • Cat. No. CS-0187813
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NO₃S
  • Molecular Weight 159.16
  • Synonym(s) 5-thiazolecarboxylic acid, 2-hydroxy-4-methyl-
  • SMILES CC1=C(C(=O)O)SC(=N1)O

Description

2-Hydroxy-4-methylthiazole-5-carboxylic acid features a fused heterocyclic core with strategically positioned hydroxyl, methyl, and carboxylic acid groups enabling versatile conjugation. This bench-stable scaffold integrates readily into synthetic workflows requiring polar, electron-deficient motifs for medicinal chemistry or materials applications.

Application

2-Hydroxy-4-methylthiazole-5-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its dual functionality—phenolic hydroxyl and carboxylic acid—enables facile derivatization via amidation, esterification, or metal-catalyzed coupling reactions. The molecule exhibits good bench stability and facilitates purification through crystallization or standard chromatographic methods, supporting its use in scalable synthesis of thiazole-based pharmacophores and functionalized polymers.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   70.42
  • LogP   0.85532
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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