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Structure of 877149-08-1
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4-Bromo-2-methoxy-6-methylbenzoic acid features a trifunctional aromatic core with bromine, methoxy, and methyl groups positioned ortho to the carboxylic acid. This electron-deficient scaffold enables direct coupling in cross-coupling reactions and serves as a building block for bioactive molecules. The compound exhibits enhanced solubility in organic solvents and stability under standard bench conditions.
4-Bromo-2-methoxy-6-methylbenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering predictable reactivity for Suzuki-Miyaura and Stille couplings. The carboxylic acid group enables direct derivatization to amides, esters, or acyl chlorides, while the bromine facilitates palladium-catalyzed cross-coupling. The methoxy and methyl groups provide steric and electronic modulation, enhancing metabolic stability and lipophilicity in target molecules. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthetic sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: