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CS-W001157 4
Total: USD 88.00

3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine

  • CAS No. 877173-84-7

  • Cat. No. CS-W019228
  • Purity≥97%
  • MDL No.MFCD12755892

*For research and further manufacturing use only, not for direct human use.

3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine|CS-W019228

Structure of 877173-84-7

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General Information

  • CAS No. 877173-84-7
  • Cat. No. CS-W019228
  • Purity ≥97%
  • MDL No. MFCD12755892
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClN₃
  • Molecular Weight None
  • Synonym(s) None
  • SMILES ClC1=CC=NC2=C(Br)C=NN12

Description

3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine features a fused heterocyclic core with orthogonal halogen substituents enabling selective cross-coupling reactions. The bromine at the 3-position and chlorine at the 7-position provide complementary reactivity for sequential functionalization in medicinal chemistry and materials synthesis under standard conditions.

Application

3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization via Pd-catalyzed cross-coupling reactions. The bromo and chloro substituents provide orthogonal reactivity for sequential derivatization, while the pyrazolopyrimidine core offers structural rigidity and hydrogen-bonding capacity. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of kinase inhibitors and other heterocyclic scaffolds.

Synthesis

  • Route1

    References

    • EIRX THERAPEUTICS LIMITED Patent: WO2007/17678 A1, 2007 ; Location in patent: Page/Page column 44-45 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   2.1452
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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