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crizotinib impurity 1

  • CAS No. 877397-70-1

  • Cat. No. CS-M0264
  • Purity≥98%
  • MDL No.MFCD18207059

*For research and further manufacturing use only, not for direct human use.

crizotinib impurity 1|CS-M0264

Structure of 877397-70-1

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General Information

  • CAS No. 877397-70-1
  • Cat. No. CS-M0264
  • Purity ≥98%
  • MDL No. MFCD18207059
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₉Cl₂FN₂O₃
  • Molecular Weight 331.13
  • Synonym(s) None
  • SMILES FC1=C(C([C@@H](C)OC2=C([N+]([O-])=O)N=CC=C2)=C(Cl)C=C1)Cl

Synthesis

  • Route1

    References

    • PFIZER INC. Patent: WO2006/21886 A1, 2006 ; Location in patent: Page/Page column 51 ; WO 2006/021886 A1
  • Route2

    References

    • CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD; XI, Ning; WANG, Ruyong; WANG, Liang Patent: WO2014/89324 A1, 2014 ; Location in patent: Paragraph 0173 ;
  • Route3

    References

    • PFIZER INC. Patent: WO2006/21881 A2, 2006 ; Location in patent: Page/Page column 59 ; WO 2006/021881 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.26
  • LogP   4.5757
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

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