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Structure of 88071-91-4
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Methyl 5-(bromomethyl)-2-nitrobenzoate features a bromomethyl group flanked by a nitro substituent and ester functionality, enabling direct functionalization in cross-coupling and nucleophilic substitution reactions. The electron-deficient aromatic ring enhances reactivity, while the bench-stable ester moiety ensures reliable handling under standard conditions.
Methyl 5-(bromomethyl)-2-nitrobenzoate serves as a versatile building block for heterocyclic synthesis, enabling efficient construction of biologically relevant scaffolds. The bromomethyl group exhibits high reactivity in nucleophilic substitution reactions, facilitating coupling with amines, thiols, and azide derivatives under mild conditions. Its nitro group enhances electrophilicity at the aromatic ring and supports subsequent reduction and functionalization steps. The compound demonstrates excellent bench stability and is readily purified by flash chromatography, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331-H341
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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Lot numbers can be found on the outside label of a product: