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CS-W001157 4
Total: USD 88.00

(2-Fluoro-5-(trifluoromethoxy)phenyl)boronic acid

  • CAS No. 881402-22-8

  • Cat. No. CS-W014228
  • Purity≥97%
  • MDL No.MFCD09027234

*For research and further manufacturing use only, not for direct human use.

(2-Fluoro-5-(trifluoromethoxy)phenyl)boronic acid|CS-W014228

Structure of 881402-22-8

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General Information

  • CAS No. 881402-22-8
  • Cat. No. CS-W014228
  • Purity ≥97%
  • MDL No. MFCD09027234
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BF₄O₃
  • Molecular Weight None
  • Synonym(s) 2-FLUORO-5-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID
  • SMILES FC(F)(F)OC1=CC=C(F)C(B(O)O)=C1

Description

This boronic acid features a fluorinated aryl moiety paired with a trifluoromethoxy group, delivering enhanced stability and electron-deficient character. It integrates efficiently into Suzuki-Miyaura cross-coupling reactions under standard conditions, enabling rapid access to complex fluorinated biaryls and heterocycles.

Application

(2-Fluoro-5-(trifluoromethoxy)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds with enhanced metabolic stability. Its trifluoromethoxy group imparts favorable electronic and lipophilic properties, while the boronic acid functionality offers excellent bench stability and compatibility with diverse reaction conditions. The compound facilitates the synthesis of fluorinated heterocycles and pharmaceutical intermediates under standard catalytic protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.4041
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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