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CS-W001157 4
Total: USD 88.00

Amlodipine impurity 4

  • CAS No. 88150-62-3

  • Cat. No. CS-0136897
  • Purity≥98%
  • MDL No.MFCD07782096

*For research and further manufacturing use only, not for direct human use.

Amlodipine impurity 4|CS-0136897

Structure of 88150-62-3

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General Information

  • CAS No. 88150-62-3
  • Cat. No. CS-0136897
  • Purity ≥98%
  • MDL No. MFCD07782096
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₈H₂₇ClN₂O₇
  • Molecular Weight 538.98
  • Synonym(s) Phthaloyl Amlodipine
  • SMILES O=C(OC)C1=C(NC(=C(C(=O)OCC)C1C=2C=CC=CC2Cl)COCCN3C(=O)C=4C=CC=CC4C3=O)C

Description

2-Pentylfuran is a volatile heterocyclic compound mainly associated with the flavor of reverted soybean oil. It is reported to be formed by the auto-oxidation of linolenic acid.

Application

Phthaloylamlodipine serves as a protected derivative of l-amlodipine, enabling controlled release and improved stability during synthetic manipulations. Its phthaloyl group facilitates orthogonal protection of the primary amine, allowing selective deprotection under mild conditions. This compound functions as a key intermediate in the synthesis of l-amlodipine analogs and related calcium channel blockers, offering enhanced bench stability and compatibility with standard coupling and purification workflows.

Synthesis

  • Route1

    References

    • MATRIX LABORATORIES LTD Patent: WO2006/3672 A1, 2006 ; Location in patent: Page/Page column 6; 7 ;
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   111.24
  • LogP   3.6038
  • H_Acceptors   8
  • H_Donors   1
  • Rotatable_Bonds   9

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