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Structure of 883502-14-5
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1-Fluoro-2-iodo-3-methylbenzene features a trifluorinated aromatic core with strategically positioned halogens enabling direct cross-coupling reactions. The ortho-fluoro and iodo substituents facilitate palladium-catalyzed transformations, while the methyl group enhances solubility and modulates electronic effects. This compound serves as a key intermediate in the synthesis of functionalized biaryls and pharmaceutical scaffolds under standard conditions.
1-Fluoro-2-iodo-3-methylbenzene serves as a versatile ortho-diaryl building block for palladium-catalyzed cross-coupling reactions. The fluorine and iodine substituents enable sequential functionalization via orthogonal reactivity, with the iodide undergoing efficient coupling under mild conditions. The methyl group provides steric and electronic modulation, enhancing stability and facilitating purification. This compound functions reliably in Suzuki-Miyaura, Stille, and Negishi couplings, offering predictable regiocontrol for complex aromatic scaffold construction.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: