Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Bromo-3-methoxybenzoic acid

  • CAS No. 88377-29-1

  • Cat. No. CS-W005119
  • Purity≥96%
  • MDL No.MFCD11848447

*For research and further manufacturing use only, not for direct human use.

2-Bromo-3-methoxybenzoic acid|CS-W005119

Structure of 88377-29-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 88377-29-1
  • Cat. No. CS-W005119
  • Purity ≥96%
  • MDL No. MFCD11848447
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrO₃
  • Molecular Weight 231.04
  • Synonym(s) None
  • SMILES O=C(O)C1=CC=CC(OC)=C1Br

Description

2-Bromo-3-methoxybenzoic acid features a bromine substituent at the ortho position relative to the carboxylic acid, paired with a methoxy group in the adjacent meta orientation. This electronic and steric profile enables selective coupling reactions in synthetic routes to bioactive molecules. The compound exhibits enhanced solubility in organic solvents and stability under standard bench conditions, facilitating its use in pharmaceutical intermediates and materials chemistry.

Application

2-Bromo-3-methoxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the aromatic ring via palladium-catalyzed cross-coupling reactions. The bromo group facilitates C–C bond formation under standard Suzuki, Stille, or Negishi conditions, while the methoxy and carboxylic acid functionalities offer orthogonal handles for further derivatization. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative synthesis of bioactive heterocycles and API intermediates.

Synthesis

  • Route1
    • 2-Amino-3-(methyloxy)benzoic acid Alogliptin Impurity|CS-0228715
      3177-80-8
    • ~82%
    • In-stock
      2-Bromo-3-methoxybenzoic acid|CS-W005119
      88377-29-1

    References

    • Huszthy, Peter; Koentoes, Zoltan; Vermes, Borbala; Pinter, Aron Tetrahedron, 2001 , vol. 57, # 23 p. 4967 - 4975
  • Route2

    References

    • Nguyen, Thi-Huu; Chau, Nguyet Trang Thanh; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3419 - 3429
  • Route3

    References

    • Menzel, Karsten; Dimichele, Lisa; Mills, Paul; Frantz, Doug E.; Nelson, Todd D.; Kress, Michael H. Synlett, 2006 , # 12 p. 1948 - 1952

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.1559
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Bromo-3-methoxybenzoic acid sigma2-Bromo-3-methoxybenzoic acid manufacturer2-Bromo-3-methoxybenzoic acid price2-Bromo-3-methoxybenzoic acid structure2-Bromo-3-methoxybenzoic acid SDSbuy 2-Bromo-3-methoxybenzoic acid2-Bromo-3-methoxybenzoic acid supplier2-Bromo-3-methoxybenzoic acid uses2-Bromo-3-methoxybenzoic acid molecular weightprice of 2-Bromo-3-methoxybenzoic acid2-Bromo-3-methoxybenzoic acid chemical name formula of 2-Bromo-3-methoxybenzoic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label