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CS-W001157 4
Total: USD 88.00

3-Bromo-5-fluoro-2-methoxypyridine

  • CAS No. 884494-81-9

  • Cat. No. CS-W003209
  • Purity≥98%
  • MDL No.MFCD04972397
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5-fluoro-2-methoxypyridine|CS-W003209

Structure of 884494-81-9

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Description

3-Bromo-5-fluoro-2-methoxypyridine features a pyridine core functionalized with bromo, fluoro, and methoxy groups at distinct positions, enabling selective cross-coupling and derivatization. The electron-deficient ring facilitates palladium-catalyzed reactions, while the methoxy group enhances solubility and stability under standard conditions. This scaffold serves as a key intermediate in pharmaceutical synthesis and materials chemistry.

Application

3-Bromo-5-fluoro-2-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates efficient C–C bond formation, while the fluoro and methoxy substituents provide tunable electronic and steric properties. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex heterocyclic scaffolds in API development.

General Information

  • CAS No. 884494-81-9
  • Cat. No. CS-W003209
  • Purity ≥98%
  • MDL No. MFCD04972397
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFNO
  • Molecular Weight 206.01
  • Synonym(s) 3-Bromo-5-fluoro-2-methoxypyrdine; 3-Bromo-5-fluoro-2-methoxypyridine
  • SMILES COC1=NC=C(F)C=C1Br

Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.9918
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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