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CS-W001157 4
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4-Bromo-5-fluoro-2-hydroxypyridine

  • CAS No. 884495-01-6

  • Cat. No. CS-W022108
  • Purity≥98%
  • MDL No.MFCD05662410

*For research and further manufacturing use only, not for direct human use.

4-Bromo-5-fluoro-2-hydroxypyridine|CS-W022108

Structure of 884495-01-6

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General Information

  • CAS No. 884495-01-6
  • Cat. No. CS-W022108
  • Purity ≥98%
  • MDL No. MFCD05662410
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrFNO
  • Molecular Weight 191.99
  • Synonym(s) 4-bromo-5-fluoro-pyridin-2-ol
  • SMILES OC1=NC=C(F)C(Br)=C1

Description

4-Bromo-5-fluoro-2-hydroxypyridine features a uniquely functionalized pyridine core bearing bromo, fluoro, and hydroxyl groups at strategic positions. This combination enables direct coupling in cross-coupling reactions and facilitates downstream derivatization in medicinal chemistry. The molecule exhibits enhanced reactivity due to the electron-withdrawing halogens adjacent to the hydroxyl group, promoting nucleophilic substitution pathways under mild conditions. Its bench-stable nature supports reliable handling in synthetic workflows.

Application

4-Bromo-5-fluoro-2-hydroxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The hydroxyl group supports direct functionalization or protection strategies, while the fluorine and bromine substituents provide tunable electronic effects and sites for further derivatization. Its bench-stable nature and compatibility with standard synthetic protocols facilitate efficient access to substituted pyridine scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.6888
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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