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Structure of 884495-01-6
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4-Bromo-5-fluoro-2-hydroxypyridine features a uniquely functionalized pyridine core bearing bromo, fluoro, and hydroxyl groups at strategic positions. This combination enables direct coupling in cross-coupling reactions and facilitates downstream derivatization in medicinal chemistry. The molecule exhibits enhanced reactivity due to the electron-withdrawing halogens adjacent to the hydroxyl group, promoting nucleophilic substitution pathways under mild conditions. Its bench-stable nature supports reliable handling in synthetic workflows.
4-Bromo-5-fluoro-2-hydroxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The hydroxyl group supports direct functionalization or protection strategies, while the fluorine and bromine substituents provide tunable electronic effects and sites for further derivatization. Its bench-stable nature and compatibility with standard synthetic protocols facilitate efficient access to substituted pyridine scaffolds relevant to pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: