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Structure of 885271-25-0
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Methyl 3-iodo-1H-indazole-5-carboxylate is a bench-stable, moisture-tolerant building block featuring a strategically positioned iodine atom at the 3-position and a carboxylate ester at the 5-position. This combination enables efficient late-stage diversification via cross-coupling reactions, particularly in palladium-catalyzed transformations. The electron-deficient indazole core enhances reactivity in Suzuki-Miyaura and Negishi protocols, while the methyl ester group provides synthetic handle flexibility for downstream derivatization.
Methyl 3-iodo-1H-indazole-5-carboxylate serves as a versatile building block for transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The iodide functionality exhibits high reactivity in palladium-catalyzed coupling processes, while the methyl ester group provides compatibility with standard functional group manipulations. Its bench-stable nature and orthogonal reactivity profile facilitate integration into multi-step synthetic sequences for medicinal chemistry and materials science applications.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: