1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)cyclobutane-1-carboxylic acid

Name: 1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)cyclobutane-1-carboxylic acid
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CAS No. 885951-77-9
Cat. No. CS-0130262
Purity≥98%
MDL No.MFCD02682624

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1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)cyclobutane-1-carboxylic acid|CS-0130262

Structure of 885951-77-9

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Description

This fluorenylmethoxycarbonyl-protected cyclobutane derivative serves as a robust, bench-stable amino acid surrogate for peptide synthesis. The rigid cyclobutane scaffold imparts conformational constraint, while the Fmoc group enables orthogonal deprotection. Ideal for incorporating sterically defined residues into bioactive peptides and cyclic architectures.

Application

1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)cyclobutane-1-carboxylic acid serves as a robust, bench-stable amino acid derivative for peptide synthesis. The Fmoc group enables efficient N-terminal protection with orthogonal deprotection under mild basic conditions. The cyclobutane core provides conformational rigidity, facilitating the incorporation of constrained motifs in bioactive peptide sequences. Compatible with standard coupling protocols and offering clean purification via crystallization or chromatography, this building block supports scalable synthesis of cyclic peptides and peptidomimetics.

General Information

CAS No. 885951-77-9
Cat. No. CS-0130262
Purity ≥98%
MDL No. MFCD02682624
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₁₉NO₄
Molecular Weight 337.37
Synonym(s) 1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)cyclobutanecarboxylic acid
SMILES O=C(C1(NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)CCC1)O

Computational Chemistry Data

TPSA 75.63
LogP 3.5324
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 4

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Life Science Amino Acids and their Derivatives Alanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)cyclobutane-1-carboxylic acid

CAS No. 885951-77-9

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