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Structure of 885952-85-2
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4-Methylpyrrolidine-3-carboxylic acid is a conformationally constrained, sterically hindered proline analog featuring a methyl group at the C4 position. This substitution enhances metabolic stability and modulates electronic properties, enabling improved membrane permeability. The carboxylic acid moiety facilitates direct incorporation into peptide scaffolds via standard coupling protocols.
4-Methylpyrrolidine-3-carboxylic acid serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of pyrrolidine-containing bioactive molecules. Its well-defined stereochemistry and stability under standard reaction conditions facilitate efficient incorporation into peptide-like scaffolds and heterocyclic frameworks. The carboxylic acid group allows for direct derivatization or coupling reactions, while the methyl substituent enhances metabolic stability and modulates physicochemical properties. This compound functions effectively in both solution-phase and solid-phase synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: