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5-Bromo-2-(trifluoromethoxy)pyridine

  • CAS No. 886371-77-3

  • Cat. No. CS-0057776
  • Molecule weight241.99
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-(trifluoromethoxy)pyridine|CS-0057776

Structure of 886371-77-3

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General Information

  • CAS No. 886371-77-3
  • Cat. No. CS-0057776
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrF₃NO
  • Molecular Weight 241.99
  • Synonym(s) 5-Bromo-2-trifluoromethoxypyridine
  • SMILES C1=CC(=NC=C1Br)OC(F)(F)F

Description

5-Bromo-2-(trifluoromethoxy)pyridine features a trifluoromethoxy group that enhances electron-withdrawal and metabolic stability, while the bromine substituent enables efficient cross-coupling. This pyridine scaffold serves as a key building block in medicinal chemistry for constructing bioactive heterocycles under standard conditions.

Application

5-Bromo-2-(trifluoromethoxy)pyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-defined reactivity at the bromine site. The trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the pyridine scaffold provides a robust platform for further functionalization. Its bench-stable nature and compatibility with standard coupling protocols make it a practical choice for constructing complex heterocyclic architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P264-P270-P330

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.7427
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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