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Structure of 886496-49-7
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4-Fluoro-3-(trifluoromethoxy)benzoic acid features a strategically positioned trifluoromethoxy group enhancing electron-withdrawal and metabolic stability. This aromatic carboxylic acid integrates readily into bioactive scaffolds, offering improved solubility and membrane permeability in medicinal chemistry applications.
4-Fluoro-3-(trifluoromethoxy)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its orthogonal functional groups—fluorine and trifluoromethoxy—offer enhanced metabolic stability and modulated lipophilicity, while the carboxylic acid facilitates direct derivatization or coupling reactions. The compound exhibits excellent bench stability and is compatible with standard synthetic workflows, including amide formation, Suzuki-Miyaura coupling, and electrophilic aromatic substitution.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: