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Structure of 886498-08-4
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2-Fluoro-5-(trifluoromethoxy)benzonitrile features a trifluoromethoxy group flanked by fluorine and nitrile substituents, creating a highly electron-deficient aromatic core. This combination enhances reactivity in transition metal-catalyzed coupling processes while maintaining bench-stable handling properties under standard conditions.
2-Fluoro-5-(trifluoromethoxy)benzonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated heterocycles and bioactive scaffolds. Its ortho-fluoro and trifluoromethoxy groups enhance metabolic stability and modulate electronic properties, while the nitrile functionality supports diverse transformations including hydrolysis, reduction, and nucleophilic addition. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for scalable synthesis and API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: