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CS-W001157 4
Total: USD 88.00

(4-(2,2,2-Trifluoroethoxy)phenyl)boronic acid

  • CAS No. 886536-37-4

  • Cat. No. CS-W014761
  • Purity≥95%
  • MDL No.MFCD09027239

*For research and further manufacturing use only, not for direct human use.

(4-(2,2,2-Trifluoroethoxy)phenyl)boronic acid|CS-W014761

Structure of 886536-37-4

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General Information

  • CAS No. 886536-37-4
  • Cat. No. CS-W014761
  • Purity ≥95%
  • MDL No. MFCD09027239
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BF₃O₃
  • Molecular Weight 219.95
  • Synonym(s) boronic acid, B-[4-(2,2,2-trifluoroethoxy)phenyl]-
  • SMILES FC(F)(F)COC1=CC=C(B(O)O)C=C1

Description

This boronate moiety integrates a trifluoromethyl ether group, enhancing solubility and metabolic stability. The electron-withdrawing trifluoroethoxy substituent improves reaction efficiency in Suzuki-Miyaura couplings. Bench-stable under standard conditions, it enables reliable C–C bond formation with aryl halides and pseudohalides.

Application

(4-(2,2,2-Trifluoroethoxy)phenyl)boronic acid serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. Its trifluoroethoxy group enhances solubility and metabolic stability while maintaining compatibility with standard reaction conditions. The boronic acid moiety enables efficient C–C bond formation with aryl halides and pseudohalides, facilitating the construction of complex biaryl architectures relevant to pharmaceutical and agrochemical synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.3075
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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