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Structure of 887147-19-5
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4,6-Dichloro-1-methyl-1H-imidazo[4,5-c]pyridine is a sterically hindered, bench-stable heterocycle featuring two electron-deficient chlorine substituents at the 4- and 6-positions. This configuration enhances electrophilicity at the imidazopyridine core, enabling efficient coupling in cross-coupling reactions. The methyl group at N1 improves solubility and reduces basicity, facilitating handling in synthetic workflows.
4,6-Dichloro-1-methyl-1H-imidazo[4,5-c]pyridine serves as a versatile building block for constructing biologically relevant heterocyclic scaffolds. The dichloro substitution enables regioselective cross-coupling reactions, while the methylated imidazopyridine core offers enhanced stability and favorable solubility. It functions as a key intermediate in the synthesis of kinase inhibitors and other pharmaceutical candidates, with predictable reactivity under standard Suzuki-Miyaura and Buchwald-Hartwig conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: