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CS-W001157 4
Total: USD 88.00

6-Chloro-2-nitropyridin-3-ol

  • CAS No. 887471-39-8

  • Cat. No. CS-0096483
  • Purity≥98%
  • MDL No.MFCD09834122
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-nitropyridin-3-ol|CS-0096483

Structure of 887471-39-8

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Description

6-Chloro-2-nitropyridin-3-ol features a chlorinated pyridine core with dual electron-withdrawing nitro and hydroxyl groups positioned for orthogonal reactivity. This bench-stable scaffold enables direct coupling in cross-coupling protocols and serves as a key intermediate in the synthesis of bioactive heterocycles, particularly in medicinal chemistry and agrochemical development.

Application

6-Chloro-2-nitropyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling regioselective functionalization at the 3-position via nucleophilic substitution. The nitro group facilitates subsequent reduction to an amine, while the chloro substituent offers compatibility with palladium-catalyzed coupling reactions. Bench-stable and readily purified by recrystallization, it functions effectively in the synthesis of heterocyclic scaffolds and advanced intermediates for API development.

General Information

  • CAS No. 887471-39-8
  • Cat. No. CS-0096483
  • Purity ≥98%
  • MDL No. MFCD09834122
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₂O₃
  • Molecular Weight 174.54
  • Synonym(s) 6-Chloro-3-hydroxy-2-nitropyridine
  • SMILES OC1=CC=C(Cl)N=C1[N+]([O-])=O

Computational Chemistry Data

  • TPSA   76.26
  • LogP   1.3488
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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